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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - JNJ 303

JNJ 303

CAS No. 878489-28-2

JNJ 303( —— )

Catalog No. M20998 CAS No. 878489-28-2

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JNJ 303
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
  • Description
    JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
  • In Vitro
    JNJ 303 can block IKs with an IC50 value of 64 nM. JNJ 303 (3.3 μM) does not have any effects on other cardiac channels.JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
  • In Vivo
    JNJ 303 recapitulates the Exn4-induced decrease in fasting blood glucose level in mice.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    IKs
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    878489-28-2
  • Formula Weight
    440.98
  • Molecular Formula
    C21H29ClN2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (141.73 mM)
  • SMILES
    CC(C)(Oc1ccc(Cl)cc1)C(=O)NC1C2CC3CC1CC(NS(C)(=O)=O)(C3)C2
  • Chemical Name
    2-(4-Chloro-phenoxy)-N-(5-methanesulfonylamino-adamantan-2-yl)-2-methyl-propionamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kang C Badiceanu A Brennan J A et al. β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle[J]. Scientific Reports 2017 7(1):15922.
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